Despite the huge loss of malaria at the global level, this disease remains an important public health problem. In Brazil, 99.7% of cases occur in the Amazon region, considered as an endemic area of disease, with XX% of cases being due are P. vivax, X% for P. falciparum and P. malariae XX. In this region, the clinical spectrum of the disease ranges from asymptomatic infections to severe cases of malaria and, occasionally, death. Most of the cases corresponds to malaria with clinical symptoms are well defined and are the target of control programs for diagnosis timely and appropriate treatment. In areas of high endemicity, where individuals have had several episodes of the disease are likely to be found in a proportion of asymptomatic infections go XX to XX%, depending on the case definition. The severe malaria is an uncommon event as well as the malaria mortality and has been decreasing year by year. In 2015 the number of hospitalizations and deaths from malaria was XX in this region.
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